Health Nucleus world-class physicians and genomic scientists

Uniquely skilled. Relentlessly dedicated. Meet the people behind the science.

No matter how advanced the science and technology, it’s the people applying it that have the power to make the biggest impact. Our physicians combine their passion for medicine with a deep and sincere desire to treat the whole person and not just their symptoms. They are particularly skilled in interpreting large data sets to glean critical health information that can be acted upon to preempt disease and drive optimal health through a unique combination of traditional, integrative and functional medicine.

Health Nucleus Physicians Group

David Karow, MD, PhD, As Chief of Performance Medicine and Medical Imaging for Health Nucleus

David Karow, MD, PhD

As President and Chief of Radiology for Health Nucleus, I am on a mission to optimize the longevity and personal performance of our patients. My goal for Health Nucleus is to change sick” care to health care, as the leader of whole genome genetic interpretation, whole body imaging, and advanced blood work.

EDUCATION

B.S, University of Michigan, Concentration: Cellular and Molecular Biology (1994)
MD, PH.D in Cellular and Molecular Biology  University of Michigan (2005)

Internship in Internal Medicine, University of California, Irvine (2005 - 2006)

Residency in Diagnostic Radiology, University of California, San Diego (July 2006 – June 2011)

Fellowship in Abdominal Imaging and Cross-sectional Interventional, University of California, Los Angeles (2011 – 2012)

ACCREDITATIONS

Medical Board of California, Physician and Surgeon (2006 – present)
Board Certified, American Board of Radiology, Diagnostic (2011 – present)
California X-Ray Supervisor & Operator Permit,  (2011 – present)

PUBLICATIONS

Precision Medicine Integrating Whole-Genome Sequencing, Comprehensive Metabolomics, and Advanced Imaging
“Genome sequencing has established clinical utility for rare disease diagnosis. While increasing numbers of individuals have undergone elective genome sequencing, a comprehensive study surveying genome-wide disease-associated genes in adults with deep phenotyping has not been reported. Here we report the results of a 3-y precision …”

An Unsupervised Learning Approach to Identify Novel Signatures of Health and Disease From Multimodal Data
“…multimodal data integration, from the identification of novel biomarker signatures to a data-driven stratification of individuals into disease subtypes and stages-an essential step towards personalized, preventative health risk assessment.”

Utility of Restriction Spectrum Imaging Among Men Undergoing First-Time Biopsy for Suspected Prostate Cancer
“Evaluate restriction spectrum imaging (RSI) in men undergoing MRI-ultrasound fusion biopsy for suspected prostate cancer (PCa) and to compare the performance of RSI.. “

Relationship Between Kurtosis and Bi-Exponential Characterization of High B-Value Diffusion-Weighted Imaging: Application to Prostate Cancer
“High b-value diffusion-weighted imaging has application in the detection of cancerous tissue across multiple body sites. Diffusional kurtosis and bi-exponential modeling are two popular model-based techniques…”

Precision Medicine Screening Using Whole-Genome Sequencing and Advanced Imaging to Identify Disease Risk in Adult
“Using genomics in combination with advanced imaging and other clinical testing to proactively screen for age-related chronic disease...”

Polygenic Hazard Score to Guide Screening for Aggressive Prostate Cancer: Development and Validation in Large Scale Cohorts
“Predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen…”

Genetic Assessment of Age-Associated Alzheimer Disease Risk: Development and Validation of a Polygenic Hazard Score
“Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk…”

Restriction Spectrum Imaging: An Evolving Imaging Biomarker in Prostate MRI
“Restriction spectrum imaging (RSI) is a novel diffusion-weighted MRI technique that uses the mathematically distinct behavior of water diffusion…”

Voxel Level Radiologic-Pathologic Validation of Restriction Spectrum Imaging Cellularity Index With Gleason Grade in Prostate Cancer
“We evaluated the reliability of RSI-MRI to predict variance with GG at the voxel-level within clinically demarcated prostate cancer”

Restriction Spectrum Imaging Improves MRI-based Prostate Cancer Detection
“To compare the diagnostic performance of restriction spectrum imaging (RSI), with that of conventional multi-parametric (MP) magnetic resonance imaging (MRI) for prostate cancer (PCa) detection”

In Vivo Prostate Cancer Detection and Grading Using Restriction Spectrum imaging-MRI
“ RSI-MRI significantly improves upon current noninvasive PCa imaging and may potentially…”

Parenchymal Volumetric Assessment as a Predictive Tool to Determine Renal Function Benefit of Nephron-Sparing Surgery Compared With Radical Nephrectomy
“Volumetric-based assessment provides information to predict postoperative eGFR. A tool based on this equation may assist surgical counseling regarding…”

Prostate Diffusion Imaging With Distortion Correction
“Diffusion imaging in the prostate is susceptible to distortion from B0 inhomogeneity. Distortion correction in prostate imaging is not routinely performed, resulting in…”

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease
“Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated…”

MRI-Derived Restriction Spectrum Imaging Cellularity Index Is Associated With High Grade Prostate Cancer on Radical Prostatectomy Specimens
“The RSI-derived normalized cellularity index is associated with aggressive PCa as determined by pathologic Gleason scores. Further utilization of RSI techniques may serve to enhance…”

Novel Technique for Characterizing Prostate Cancer Utilizing MRI Restriction Spectrum Imaging: Proof of Principle and Initial Clinical Experience With Extraprostatic Extension
“Standard magnetic resonance imaging (MRI) of the prostate lacks sensitivity in the diagnosis and staging of prostate cancer (PCa). To improve the operating characteristics of prostate MRI in the detection and characterization of PCa, we developed a novel, enhanced MRI diffusion technique…”

Diffusion-weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging“
The scope of DWI has since broadened to include oncologic imaging of the prostate gland, breast, and liver. Despite its growing success and application, misconceptions about the underlying physical basis of the DWI signal exist…”

Relative Capability of MR Imaging and FDG PET to Depict Changes Associated With Prodromal and Early Alzheimer Disease

Combining MR Imaging, Positron-Emission Tomography, and CSF Biomarkers in the Diagnosis and Prognosis of Alzheimer Disease
“To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers…”

Structural MRI Biomarkers for Preclinical and Mild Alzheimer's Disease
“Noninvasive MRI biomarkers for Alzheimer's disease (AD) may enable earlier clinical diagnosis and the monitoring of therapeutic effectiveness. To assess potential neuroimaging biomarkers, the Alzheimer's Disease Neuroimaging Initiative is following normal controls (NC) and individuals with mild cognitive impairment…”

Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases
“Homeostatic sensory systems detect small deviations in temperature, water balance, pH, and energy needs to regulate adaptive behavior and physiology. In C. elegans, a homeostatic preference for intermediate oxygen (O2) levels requires cGMP signaling through soluble guanylate cyclases (sGCs)…”

Alzheimer Disease: Quantitative Structural Neuroimaging for Detection and Prediction of Clinical and Structural Changes in Mild Cognitive Impairment
“Semiautomated, individually specific quantitative MR imaging methods can be used to identify a pattern of regional atrophy in MCI…”

Multi-modal Imaging Predicts Memory Performance in Normal Aging and Cognitive Decline
“This study (n=161) related morphometric MR imaging, FDG-PET and APOE genotype to memory scores in normal controls (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD). Stepwise regression analyses focused on morphometric and metabolic characteristics of the episodic memory network…”

A Distributed Chemosensory Circuit for Oxygen Preference in C. Elegans
“The nematode Caenorhabditis elegans has complex, naturally variable behavioral responses to environmental oxygen, food, and other animals. C. elegans detects oxygen through soluble guanylate cyclase homologs (sGCs) and responds to it differently…”


Nitric Oxide Binding to Prokaryotic Homologs of the Soluble Guanylate Cyclase beta1 H-NOX Domain
“The heme cofactor in soluble guanylate cyclase (sGC) is a selective receptor for NO, an important signaling molecule in eukaryotes. The sGC heme domain has been localized to the N-terminal 194 amino acids of the beta1 subunit of sGC and is a member of a family of conserved hemoproteins, called the H-NOX family…”

Characterization of Functional Heme Domains From Soluble Guanylate Cyclase
“Soluble guanylate cyclase (sGC) is a heterodimeric, nitric oxide (NO)-sensing hemoprotein composed of two subunits, alpha1 and beta1. NO binds to the heme cofactor in the beta1 subunit…”

Crystal Structure of an Oxygen-Binding Heme Domain Related to Soluble Guanylate Cyclases
“Soluble guanylate cyclase (sGC) is a heterodimeric, nitric oxide (NO)-sensing hemoprotein composed of two subunits, alpha1 and beta1. NO binds to the heme cofactor in the beta1 subunit, forming a five-coordinate NO complex that activates the enzyme several hundred-fold…This paper has identified and characterized the minimum functional ligand-binding heme domain derived from sGC…”

Spectroscopic Characterization of the Soluble Guanylate Cyclase-Like Heme Domains From Vibrio Cholerae and Thermoanaerobacter Tengcongensis
“Soluble guanylate cyclase (sGC) is a nitric oxide- (NO-) sensing hemoprotein that has been found in eukaryotes from Drosophila to humans. Prokaryotic proteins with significant homology to the heme domain of sGC have recently been identified through genomic analysis…The first is a 181 amino acid protein cloned from Vibrio cholera…The second protein is the N-terminal 188 amino acids of Tar4…”

Oxygen Sensation and Social Feeding Mediated by a C. Elegans Guanylate Cyclase Homologue
“Specialized oxygen-sensing cells in the nervous system generate rapid behavioural responses to oxygen. We show here that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5-12% oxygen…”

RNA Polymerase II-dependent Positional Effects on mRNA 3' End Processing in the Adenovirus Major Late Transcription Unit
“Our results are consistent with recent reports demonstrating that the processing factors cleavage and polyadenylation specificity factor and cleavage stimulatory factor are associated with the RNA polymerase II holoenzyme…”


Keith Vaux, MD

Physician in Chief and Chief Medical Officer, Human Longevity Inc | Medical Director, Health Nucleus by Human Longevity San Diego

EDUCATION

1982 - 1984 Human Sciences: Oxford University, Mansfield College, Oxford, England
1984 – 1987 B.A.: History, Philosophy and Social Studies of Science and Medicine, University of Chicago, Chicago, IL
1990 - 1994 M.D.: University of Chicago, Pritzker School of Medicine, Chicago, IL
1994 - 1995 Internship, Naval Medical Center, San Diego CA
1995 - 1997 Residency, Pediatrics Naval Medical Center, San Diego CA
1996 - 1997 Chief Residency: Pediatrics, Naval Medical Center, San Diego CA
2001 - 2004 Fellowship: Dysmorphology and Medical Genetics with additional certificate in Teratology, University of California, San Diego, CA.

ACCREDITATIONS

California Medical License, Active
American Board of Pediatrics, Active
Drug Enforcement Administration, Controlled Substance Registration Certification
Pediatric Advanced Life Support Certification
Basic Life Support Certification

PUBLICATIONS

Selected Publications

N. Revencu, L.M. Boon, J.B. Mulliken, O. Enjolras, M.R. Cordisco, P.E. Burrows, P.H. Clapuyt, F. Hammer, J. Dubois, E. Baselga, F.Brancati, B. Dallapiccola, R. Carder, G. Fischer, I. Frieden, J Harper, P. Gritters, J Johnson Patel, C. Labrèze, L. Martorell, H. J. Paltiel, A. Pohl, J. Prendiville, I. Quere, D.H. Siegel, E.M. Valente, K.K. Vaux, L. Weibel, J.M. Ceballos Quintal, D. Chitayat and M. Vikkula. “Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies and specific neural tumors associated with RASA1 mutations.” Human Mutation. 2008 Apr 29.

Dimmock D, Trapane P, Feigenbaum A, Keegan CE, Cederbaum S, Gibson J, Gambello MJ, Vaux K, Ward P, Rice GM, Wolff JA, O'Brien WE, Fang P. “Novel human pathological mutations. Gene symbol: ASS1. Disease: Citrullinaemia.” Human Genetics. 2009 Aug;126(2):341.

Dimmock DP, Trapane P, Feigenbaum A, Keegan CE, Cederbaum S, Gibson J, Gambello MJ, Vaux K, Ward P, O'Brien WE, Fang P. The role of molecular testing and enzyme analysis in the management of hypomorphic citrullinemia. American Journal of Medical Genetics A. 2010 Apr;152A(4):1061.

Eichenfield LF, Krakowski AC, Piggott C, Del Rosso J, Baldwin H, Friedlander SF, Levy M, Lucky A, Mancini AJ, Orlow SJ, Yan AC, Vaux KK, Webster G, Zaenglein AL, Thiboutot DM. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics. 2013 May;131 Suppl 3:S163-86.

Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Fenstermaker AG, Silhavy JL, Scheliga JS, Toyama K, Morisaki H, Sonmez FM, Celep F, Oraby A, Zaki MS, Al-Baradie R, Faqeih EA, Saleh MA, Spencer E, Rosti RO, Scott E, Nickerson E, Gabriel S, Morisaki T, Holmes EW, Gleeson JG. AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell. 2013 Aug 1;154(3):505-17.

Rosti RO, Sadek AA, Vaux KK, Gleeson JG. The Genetic Landscape of Autism Spectrum Disorders. Developmental Medicine and Child Neurology. 2013 Oct 1. 56(1):12-8

Gaia Novarino, Ali G. Fenstermaker, Maha S. Zaki, Matan Hofree, Jennifer L. Silhavy, Andrew D. Heiberg, Mostafa Abdellateef, Basak Rosti, Eric Scott, Lobna Mansour, Amira Masri, Hulya Kayserili, Jumana Y. Al-Aama, Ghada M.H. Abdel-Salam, Ariana Karminejad, Majdi Kara, Bulent Kara, Bita Bozorgmehri, Tawfeg Ben-Omran, Faezeh Mojahedi, Iman Gamal El Din Mahmoud, Naima Bouslam, Ahmed Bouhouche, Ali Benomar, Sylvain Hanein, Laure Raymond, Sylvie Forlani, Massimo Mascaro, Laila Selim, Nabil Shehata, Nasir Al-Allawi, P.S. Bindu, Matloob Azam, Murat Gunel, Ahmet Caglayan, Kaya Bilguvar, Asli Tolun, Mahmoud Y. Issa, Jana Schroth, Emily G. Spencer, Rasim O. Rosti, Naiara Akizu, Keith K. Vaux, Anide Johansen, Alice A. Koh, Hisham Megahed, Alexandra Durr, Alexis Brice, Giovanni Stevanin, Stacy Gabriel, Trey Ideker, Joseph G. Gleeson. Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders. Science. 2014 Jan 31;343(6170):506-11.

Akizu N, Cantagrel V, Zaki MS, Al-Gazali L, Wang X, Rosti RO, Dikoglu E, Gelot AB, Rosti B, Vaux KK, Scott EM, Silhavy JL, Schroth J, Copeland B, Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G, Abdel-Salam GM, Ozgul RK, Sagıroglu MS, Azam M, Ismail S, Aglan M, Selim L, Mahmoud IG, Abdel-Hadi S, Badawy AE, Sadek AA, Mojahedi F, Kayserili H, Masri A, Bastaki L, Temtamy S, Müller U, Desguerre I, Casanova JL, Dursun A, Gunel M, Gabriel SB, de Lonlay P, Gleeson JG. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nature Genetics. 2015 May;47(5):528-34.

Chambers, CD; Zellner, JA, Feldman, H; Akshoomoff, N; Xu, R; Coles, CD; Kable, JA; Manning, M; Adam, M; Vaux, K; Developing A Valid Prevalence Estimate For Fetal Alcohol Spectrum Disorders In A Large, Diverse Urban US Community. Alcoholism: Clinical & Experimental Research. 2015 June: 260A

Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nature Genetics. 2015 Jul;47(7):809-13.

Roosing S, Hofree M, Kim S, Scott E, Copeland B, Romani M, Silhavy JL, Rosti RO, Schroth J, Mazza T, Miccinilli E, Zaki MS, Swoboda KJ, Milisa-Drautz J, Dobyns WB, Mikati M, İncecik F, Azam M, Borgatti R, Romaniello R, Boustany RM, Clericuzio CL, D'Arrigo S, Strømme P, Boltshauser E, Stanzial F, Mirabelli-Badenier M, Moroni I, Bertini E, Emma F, Steinlin M, Hildebrandt F, Johnson CA, Freilinger M, Vaux KK, Gabriel SB, Aza-Blanc P, Heynen-Genel S, Ideker T, Dynlacht BD, Lee JE, Valente EM, Kim J, Gleeson JG. Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome. Elife (Howard Hughes Foundation). 2015 May 30;4.

Rosti RO, Dikoglu E, Zaki MS, Abdel-Salam G, Makhseed N, Sese JC, Musaev D, Rosti B, Harbert MJ, Jones MC, Vaux KK, Gleeson JG. Extending the mutation spectrum for Galloway-Mowat syndrome to include homozygous missense mutations in the WDR73 gene. American Journal of Medical Genetics. Part A. 2016; 170A(4):992-8.

Ilse Meerschaut, Justine Pètre, Nicole Revencu, Damien Lederer, Milen Vilenov, Thomy de Ravel, Djalila Mekahli, Keith Vaux, Jonathan Sebat, Fadi Hamdan, Jacques Michaud, Pablo Lapunzina, Nataliya Di Donato, Louanne Hudgins, Andrea Hanson- Kahn, Bruno Dallapiccola, Antonio Novelli, Joris Andrieux, Magdalena Budisteanu and Bert Callewaert. FOXP1-related Intellectual Disability Syndrome: a Recognizable Entity. Belgian Journal of Pediatrics, 2016 18:99–99.

Brandler WM, Antaki D, Gujral M, Noor M, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fuentes Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM Corsello C, and Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. American Journal of Human Genetics. 2016 Apr 7;98(4):667-79.

Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 Apr 20;360(6386):327-331.

Meerschaut I, Rochefort D, Revençu N, Pètre J, Corsello C, Rouleau Ga, Hamdan Ff, Michaud Jl, Morton J, Radley J, Ragge N, García-Miñaúr S, Lapunzina P, Bralo Mp, Mori Má, Moortgat S, Benoit V, Mary S, Bockaert N, Oostra A, Vanakker O, Velinov M, De Ravel Tj, Mekahli D, Sebat J, Vaux KK, Didonato N, Hanson-Kahn Ak, Hudgins L, Dallapiccola B, Novelli A, Tarani L, Andrieux J, Parker Mj, Neas K, Ceulemans B, Schoonjans As, Prchalova D, Havlovicova M, Hancarova M, Budisteanu M, Dheedene A, Menten B, Dion Pa, Lederer D, Callewaert B. Foxp1-Related Intellectual Disability Syndrome: A Recognisable Entity. Journal Of Medical Genetics 2017;54:613-623.

May PA, Chambers CD, Kalberg WO, Zellner J, Feldman H, Buckley D, Kopald D, Hasken JM, Xu R, Honerkamp-Smith G, Taras H, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Vaux K, Jewett T, Elliott AJ, Kable JA, Akshoomoff N, Falk D, Arroyo JA, Hereld D, Riley EP, Charness ME, Coles CD, Warren KR, Jones KL, Hoyme HE. Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. Journal of the American Medical Association (JAMA). 2018 Feb 6;319(5):474-482.

Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. American Journal of Human Genetics. 2018 Sep 6;103(3):431-439. Epub 2018 Aug 9. Erratum in: Am J Hum Genet. 2018 Nov 1;103(5):826.

Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. American Journal of Human Genetics. 2018 Nov 1;103(5):826.

Chambers CD, Johnson DL, Xu R, Luo Y, Lopez-Jimenez J, Adam MP, Braddock SR, Robinson LK, Vaux K, Lyons Jones K; OTIS Collaborative Research Group. Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study. PLoS One. 2019;14(10):e0223603. 2019 Oct 18.


Julie Chen, MD

Chief Clinical Officer of HLI /​ Medical Director of HLI, San Francisco

As Chief Clinical Officer for Human Longevity, I am excited to promote genomic precision medicine, as we help all our patients achieve optimal health through proactive preventive medicine. I strongly believe in being a patient advocate and working as a team with patients to stay ahead of disease and not behind it, to ensure patients live a healthy life that is functional and fulfilling. 

EDUCATION

University of Arizona, Tucson, Arizona: Arizona Center of Integrative Medicine, Integrative Medicine Fellowship

California Pacific Medical Center: San Francisco, California: Department of Internal Medicine, Internal Medicine Residency

University of Rochester School of Medicine and Dentistry, Rochester, New York: Rochester Early Medical Scholar eight-year B.A-M.D. Program; Degree: M.D. with Distinction in Research

University of Rochester, Rochester, New York: Rochester Early Medical Scholar eight-year B.A.-M.D. Program; Degree: B.A. in Public Health

Additional Education and Training

The Jones Institute, Carlsbad, California: Strain-Counterstrain Clinical Training and Certification

Palo Alto School of Hypnotherapy, Palo Alto, California: Clinical and Advanced Hypnotherapy Training and Certifications

Helms Medical Institute (UCLA Affiliate), Berkeley, California: Medical Acupuncture for Physicians including Chinese Scalp Acupuncture

ACCREDITATIONS

Board Certified in Integrative Medicine: American Board of Integrative and Holistic Medicine

University of Arizona Integrative Medicine Fellowship

HeartMath Training for Heart Rate Variability Biofeedback Completed

The Jones Institute Certification for Osteopathic Manipulations

Palo Alto School of Hypnotherapy Certification for Clinical Hypnotherapy

Board Certified in Internal Medicine American Board of Internal Medicine

PUBLICATIONS

MEDIA EXPERIENCE

2021 Medical expert featured in First for Woman Magazine, Healthline.com, TheHealthy.com, Good Housekeeping Magazine

2021 Medical expert interview featured in Authority Magazine/Thrive Global

2021 Medical expert appearance on podcast “Bootstrapping in America”

2021 Medical expert appearance on “KABC-LA News”

2020 Health.com, MSN.com, and Medium.com: featured in articles as medical expert about KN95 masks for Covid prevention

2019 Medical expert appearance on “The Doctors Show”

2018 Medical expert appearance on Facebook Live for Vitagene

2013-2014 Medical expert appearance on four different episodes of “The Dr. Oz Show”

2011-2014 Medical expert appearance on “Days with Zahrah Show”

2011-2013 Medical expert on radio shows (peopleRx, webtalkradio, BBS radio, RadioMD”

2011-2014 Medical expert interviews for magazines/online articles (Men’s Health, Real Simple, Whole Living, Huffington Post, Arthritis Today, Woman’s World, Spa Magazine, First for Woman, Costco, Pilates’ Style, Natural Solutions, Vegetarian Times, Positive Magazine, Nutritional Outlook, To Your Health, Townsend Letter, etc)

2011 Medical expert appearance on “News 12 New Jersey Health Segment”

RESEARCH EXPERIENCE

12/2002-6/2003 Division of Dermatology/Norris Cancer Center/University of Southern California, Los Angeles, CA

Honors Medical Research Fellow: Investigating the role of platelet-derived growth factor BB (PDGF-BB) in the PI-3K-Akt-P38 pathway for the migration of human dermal fibroblasts utilizing western blotting techniques and cell culturing for gold salt migration assays.

8/2001-6/2002 Dermatology Department/University of California-Irvine/Veterans Affairs-Long Beach, Long Beach, CA

Honors Medical Research Fellow: Investigating mechanisms of the differential sensitivity of epithelial cells, lymphoid cells, and liver cells to methotrexate. Composing a review article on the new treatment options for actinic keratosis. Coordinating a clinical project involving patients who are treated with topical 5-Fluorouracil therapy for the generation of patient/physician educational materials. Composing a book review on methotrexate.

6/2000-8/2000 Cardiovascular Biology Research Lab/Zena and Michael A. Wiener, Cardiovascular Institute/Mt. Sinai Medical Center New York, NY

Student Researcher: Investigating antithrombotic effects of a new inhibitor of Factor Xa of the coagulation cascade in early clinical phase trials

10/1999-5/2000 Department of Public Health at University of Rochester Rochester, NY

Research Assistant: Reviewing articles and assisting in the organization and implementation of smoking cessation program.

1998-1999  Clinical Pathology Department/Magnuson Clinical Center/National Institutes of Health, Bethesda, MD

Medical Technician: Researching seminal vesicle-specific antigen via ELISA method for prostate cancer staging marker.

9/1998-12/1998 Quality Services and Consumer Affairs Department/Lambeth, Southwark & Lewisham Health Authority, London, UK

Quality Assistant: Devising and implementing assessment programs for various National Health Service (NHS) Hospital Trusts. Researching and reporting clinical governance in the United States as resource for devising clinical governance in the NHS.

6/1997-8/1997 Laboratory of Parasitic Biology and Biochemistry/Food and Drug Administration, Bethesda, MD

Laboratory Technician: Sequencing and cloning with the purpose of DNA extraction, integration, and protein expression.

1994-1997 Laboratory of Molecular Pharmacology/National Cancer Institute/National Institutes of Health, Bethesda, MD

Student Researcher: Conducting integration and disintegration assays with HIV-1 integrase and various antiretroviral inhibitors.

JOURNAL PUBLICATIONS

Chen JT, Chinthrajah RS, Aronowitz P. A Severe Case of Tophaceous Gout. J of Hospital Medicine. 2007.

Jeffes EWB, Chen JT. New Approaches to the Treatment of Actinic Keratosis. Am J of Cancer. 2003; 2(3):151-168.

Shimbo D, Osende J, Chen J, Robbins J, Shimoto Y, Kunitada S, Fuser V, Badimon JJ. Antithrombotic Effects of DX-9065a, a Direct Factor Xa Inhibitor: a Comparative Study in Humans versus Low Molecular Weight Heparin.  Thrombosis and Haemostasis. 2002; 88(5):733-738.

Chen JT, Hortin GL. Interferences with Semen Detection by an Immunoassay for a Seminal Vesicle-Specific Antigen. J of Forensic Sciences. 2000; 45:234-235.

Nicklaus MC, Neamati N, Hong H, Mazumder A, Sunder S, Chen J, Milne GW, Pommier Y.

HIV-1 Integrase Pharmacophore: Discovery of Inhibitors Through Three-Dimensional Database Searching. J of Medicinal Chemistry. 1997; 40(6):920-929.

Mazumder A, Shaomeng W, Neamati N, Nicklaus M, Sunder S, Chen J, Milne GW, Rice WG, Burke TR,

Pommier Y. Antiretroviral Agents as Inhibitors of Both Human Immunodeficiency Virus Type I Integrase and Protease. J of Medicinal Chemistry. 1996; 39(13):2472-2481.

ABSTRACTS

4/2007 American College of Physicians Annual Session, “The Disease of Kings in a Common Man”,Chen JT, Chinthrajah, RS, Aronowitz P.  Department of Medicine, California Pacific Medical Center, San Francisco, CA

11/2006 American College of Physicians California Regional Meeting, “The Disease of Kings in a Common Man”, Chen JT, Chinthrajah RS, Aronowitz P.  Department of Medicine, California Pacific Medical Center, San Francisco, CA

2003 International Investigative Dermatology,“Requirement for the PI-3K-Akt-P38 Pathway for PDF-BB-, But Not Collagen Induced Migration of Human Dermal Fibroblast” ,Fan J, Chen J, Patrick S, Chen M, Hay N, Woodley DT, Li W.,Division of Dermatology and Norris Cancer Center,University of Southern California, Los Angeles, CA

2001 American College of Cardiology, “Antithrombotic Effects in Humans of Escalating Doses of DX-9065a, a Direct,Factor Xa Inhibitor. Comparative Study with Low Molecular Weight Heparin (Enoxaparin)”, Shimbo D, Osende J, Chen J, Mukherjee JT, Fuster V, Badimon JJ.,Department of Cardiology, Mt. Sinai School of Medicine, New York, NY

2000 University of Rochester Cancer Center 5th Annual Scientific Symposium, “Smoking Cessation in Mid-Life and Older Smokers: First-Time Quitters versus Persons with Multiple Quit Attempts”, McIntosh S, Ossip-Klein DJ, Guido JJ, Burton K, Spada J, Sesselberg T, Davis N, Friedman AL, Osorio DS, Chowdry V, Klein B, Wells K, Chen J. ,University of Rochester School of Medicine and Dentistry, Rochester, NY


Pamila Brar, MD, As the Chief Medical Director for Health Nucleus

Pamila Brar, MD

As the Chief Medical Director for Health Nucleus, I have a deep desire to translate complex medical data into accessible and actionable information that can change our patients’ lives for the better.

EDUCATION

MD, Louisiana State University School of Medicine at New Orleans (1995)

Chief Resident, Scripps Clinic Internal Medicine Residency (1998 -1999)

President of American Academy of Private Physicians, 2015-2017

ACCREDITATIONS

American Board of Internal Medicine
American Board of Integrative and Holistic Medicine

PUBLICATIONS

Precision Medicine Screening Using Whole-Genome Sequencing and Advanced Imaging to Identify Disease Risk in Adults


Mona Ezzat Velinov, MD, ABFM, ABIHM, IFMCP, Physician at Health Nucleus

Mona Ezzat Velinov, MD, ABFM, ABIHM, IFMCP

As a physician at Health Nucleus, I believe health can flourish throughout our lifetime. From the microbiome to brain health, our daily habits connect all of our systems to one amazing network.

EDUCATION

University of Iowa, Iowa City. IA., Bachelor of Arts, Biology with Honors (1991-1998)

Rush Medical College, Chicago, IL, Doctor of Medicine (1992-1996)

University of Michigan, Ann Arbor, MI Internship and Residency, Family Practice (1996-1999)

ACCREDITATIONS

American Board of Family Practice, 2017
American Board of Integrative and Holistic Medicine 2013
Institute of Functional Medicine Certified Practitioner 2019

PUBLICATIONS

Chapter: Circadian rhythm in the Digital Age in The Handbook of Wellness Medicine
To be published August, 2020


Robyn Heister, MD Physician at Health Nucleus

Robyn Heister, MD

I joined the team of physicians at Health Nucleus in 2017 with the goal of empowering patients to draw their own blueprints for healing and to continue to mentor healthcare providers on how to use emerging innovation and technology in their practice.

EDUCATION

Emergency Medicine Resident, University of California, San Diego, CA (2002-2005)

Transitional Year Internship, Scripps Mercy Hospital, San Diego, CA (2001-2002)

Doctor of Medicine, University of California at Davis, Davis, CA (1997-2001)

Coursework in Pre-Med, University of California at Los Angeles, Los Angeles, CA (1994-1997)

Bachelor of Arts in Human Biology, Emphasis on Disability & Development, Stanford University, Palo Alto, CA (1989-1993)

PeopleSeq Consortium (NIH) Participated in the ongoing efforts of NIH-funded study to evaluate the medical, behavioral and economic impact of genomic sequencing on healthy populations (2017-2019)

CEP Leadership Series, Emeryville, CA, (2012)

Credentials and Partner Affairs Committee (CPAC) for Vituity, Emeryville, CA (2010 – 2012)

American College of Emergency Physicians

California Medical Association

ACCREDITATIONS

Medical licensure California

PUBLICATIONS

Heister RR: Scaphoid Fractures. In: Rosen and Barkin’s 5-Minute Emergency Medicine Consult (second edition). Schaider J, Hayden SR, Wolfe R, Barkin RM, Rosen P (Eds.); Philadelphia: Lippincott Williams and Wilkins, 2003, pp 996-997.

Heister RR: Bone Spurs. In: Greenberg’s Atlas of Emergency Medicine. Greenberg M, Hendrickson RG, Silverberg M, Campbell CJ, Morocco A, Salvaggio C, Spencer MT (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2005.

Heister RR: Sesamoid Bones. In: Greenberg’s Atlas of Emergency Medicine. Greenberg M, Hendrickson RG, Silverberg M, Campbell CJ, Morocco A, Salvaggio C, Spencer MT (Eds.); Philadelphia: Lippincott Williams & Wilkins, 2005.

Davis DP, Heister RR, Ochs M, Hoyt D: The impact of hyperventilation on outcome following paramedic rapid sequence intubation. Neurocritical Care, accepted for publication.

Heister RR, Vadeboncouer TF, Guss DA: Impact of helical computed tomography on negative laparotomy rates in acute appendicitis. Am J Emerg Med. 2006 Jan;24 (1):43-7.

Heister RR, Rao D, Ly BT, Davis DP, Clark RF: Stingray envenomation: A retrospective review of clinical presentation and treatment of 119 cases. The Journal of Emergency Medicine 2007 July 33 (1) 33-37.

Shomorony I, Cirulli ET, Huang L, Napier, LA, Heister, RR … Unsupervised integration of multimodal dataset identifies novel signatures of health and disease. Genome Medicine. 2020 Jan 10; 12.1:7.

Hou YCC, Yu HC, Martin R, Schenker-Ahmed…Heister, RR… Precision Medicine Advancements Using Whole Genome Sequencing, Noninvasive Whole Body Imaging, and Functional Diagnostics. PNAS February 11, 2020 117(6)3053-3062.


Robert Eric Dinenberg, M.D., M.P.H.

As a Health Nucleus physician, engaging in therapeutic relationships brings me meaning and offers an opportunity to bring my passion for coaching mindfulness and other skills for peak performance to each client.

EDUCATION

Occupational Medicine Residency: UCSF Occupational and Environmental Medicine San Francisco, CA (2010.2012)

Masters of Public Health: University of California at Berkeley School of Public Health Berkeley, CA (2010.2011)

Internship, Family Practice Hennepin County Medical Center Minneapolis, MN (2000.2001)

M.D. degree: Medical College of Pennsylvania and Hahnemann University Philadelphia, PA (1994.1999)

BA with Honors in Anthropology University of California Los Angeles Los Angeles, CA (1989-1994)

ACCREDITATIONS

2002 Medical License, State of California
2002 DEA Certification
2000 Founding Diplomat, American Board of Holistic Medicine

PUBLICATIONS

Peer Reviewed Journals:

Dinenberg RE, McCaslin S, Bates M, Cohen E. Social support may protect against development of post-traumatic stress disorder: Findings from the heart and soul study. Am J Health Promot. 2014;28(5):294-7.

Book Chapters:

R E Dinenberg. Health Impact of Lifestyle and Health Promotion, In: Health Promotion in the Workplace, 4th ed. Michael O’Donnell (Ed.), Cengage Learning, Stamford, CT.

R E Dinenberg, M Zappaterra, G Pransky, J Rinker. Disability Management and Prevention. In: Current Occupational & Environmental Medicine, 5th ed., Joseph Ladou (Ed.), McGraw-Hill, NY, New York.

Industry Journals:

R E Dinenberg. Health Protection/Promotion for the Workforce: The Business Case.

Occupational Health & Safety. November 1, 2013.

http://ohsonline.com/articles/2013/11/01/health-protection-promotion-for-theworkforce.aspx

B Schmidt, R E Dinenberg. Total Worker Health Approach Helps Organizations and Employees Thrive. July 1, 2014.

http://ohsonline.com/Articles/2014/07/01/Total-Worker-Health-Approach-Helps-Organizationsand-Employees-Thrive.aspx?Page=1

R E Dinenberg. The National Diabetes Prevention Program: An Evidence-Based Program for Employers, Providers, Health Plans, and Community Groups to Bend the Trend. Managed Care Outlook. 2014;27(1)

R.E. Dinenberg. Models for Diabetes Prevention Go Beyond Traditional Approach. Managed Healthcare Executive. March 7, 2014.

Books:

Dinenberg, Mindfulness and Peak Performance: Touch the Ground, Touch the Sky; National University Press (2005).

Media:

Dinenberg, “Guided Meditations with Dr. Robert Eric Dinenberg”; iTunes Album (2010)


Keegan Duchicela, MD Physician at Health Nucleus

Keegan Duchicela, MD

As a physician specializing in preventative medicine, I am passionate about using technology to inform, empower and guide patients in their journey toward better health.

EDUCATION

Stanford University, Master of Arts, Human Biology (1999-2003)

Stanford University, Master of Arts, Sociology (2002-2003)

MD, University of California, San Francisco - School of Medicine Doctor of Medicine (2003-2007)

San Jose-O'Connor Family Medicine Residency Program (2007-2010)

ACCREDITATIONS

Board Certified, American Board of Family Physicians (2010-Present)
Board of Directors, Cachamsi Medical Spanish program

PRESENTATIONS

44th Annual STFM Spring Conference, Presenter, Wake Up! Introduce an Easy-to-Use and Affordable Audience Response System to Electrify Your Lectures; April 29th, 2011

Healthcare Information and Management Systems Society (HIMSS) National Conference, Invited panelist/ presenter, Using HealthIT to Engage Patients in Underserved Communities, March 5th 2013


Jie Liu, MD, MPH, As a physician at Health Nucleus

Jie Liu, MD, MPH

As a physician at Health Nucleus, I am passionate about using integrative medicine as well as my knowledge as a chronic disease researcher to help my patients preempt disease and create wellness.

EDUCATION

MD: University of California-San Diego 2015

Family Medicine Residency: Family Heathy Centers of San Diego 2018

MPH: Rollins School of Public Health, Emory University 2006

BA: University of Michigan, Ann Arbor, 2004

Adjunct Assistant Professor of Public Health: San Diego State University 2019-present

Core Scientist: Laura Rodriguez Research Institute, FHCSD, San Diego, CA 2019-present

ACCREDITATIONS

State of California Medical License

American Board of Family Medicine

PUBLICATIONS

Liu J, Godino JG, Norman GJ, Hill L, Calfas K, Sallis JF, Arredondo E, Rock CL, Criqui M, Zhu SH, Griffiths K, Covin J, Dillon L, Patrick K. Planned care for obesity and cardiovascular risk reduction using a stepped-down approach: A randomized-controlled trial. Prev Med. 2018 Sep;114:223-231. doi: 10.1016/j.ypmed.2018.07.015. Epub 2018 Jul 25. PubMed PMID: 30055199; PubMed Central PMCID: PMC6130909.

Cai WD, Zhao J, Zhao JK, Raymond HF, Feng YJ, Liu J, McFarland W, Gan YX, Yang ZR, Zhang Y, Tan JG, Wang XR, He ML, Cheng JQ, Chen L. HIV prevalence and related risk factors among male sex workers in Shenzhen, China: results from a time-location sampling survey. Sex Transm Infect. 2010 Feb;86(1):15-20. doi: 10.1136/sti.2009.037440. Epub 2009 Oct 22. PubMed PMID: 19854703.

Feng L, Ding X, Lu R, Liu J, Sy A, Ouyang L, Pan C, Yi H, Liu H, Xu J, Zhao J. High HIV prevalence detected in 2006 and 2007 among men who have sex with men in China's largest municipality: an alarming epidemic in Chongqing, China. J Acquir Immune Defic Syndr. 2009 Sep 1;52(1):79-85. doi: 10.1097/QAI.0b013e3181a4f53e. PubMed PMID: 19448559.


Evelyne Bischof, MD, MPH, Associate professor

As an internal medicine specialist with focus on oncology and longevity, I’m passionate to bring precision medicine by AI- and machine learning data translation towards individualized prevention and treatment. 

EDUCATION

Intern MD Massachusetts General Hospital, Beth Israel Medical Deaconess and Dana Farber (2009-2010), Columbia University (2010-2011)

MD (residency, fellowship, attending physician since 2016) University Hospital Basel, Switzerland

Associate professor Shanghai University of Medicine and Health Sciences, Shanghai (2016-now)

Lecturer, Jiaotong University School of Medicine, Shanghai (2016-now)

Associate professor Shanghai University of Medicine and Health Sciences, Shanghai (2016-now)

President of Swiss Young Internists, 2013-2020

ACCREDITATIONS

Internal medicine board certification (Switzerland)

PUBLICATIONS

Deriving Competencies for Mentors of Clinical and Translational Scholars
“We examined focus groups, the literature, competencies derived for clinical and translational scholars, mentor training curricula, mentor evaluation forms and finally conducted an expert panel process in order to compose this list.”

Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction “This study aimed to validate the diagnostic performance of the 0/1-h algorithm in a large multicenter study.”

Co-expression of CXCL8 and HIF-1α is associated with metastasis and poor prognosis in hepatocellular carcinoma “Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer mortality worldwide…”

Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit “The most important patient variables associated with the instigation of LST limitation were acute admission, frailty, age, admission SOFA score and country….”

Prognostic value of plasma levels of HIF-1a and PGC-1a in breast cancer “Therefore, in our study, we aimed to investigate the role of HIF-1α, as well as PGC-1α in breast cancer tumorigenesis, growth and metastasis…”

Anthracycline induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment (Review) “Anthracyclines are highly effective chemotherapeutic agents, used for a wide variety of malignancies. Cardiotoxicity is a well recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients.”

Pyrosequencing analysis of BRCA1 methylation level in breast cancer cells “BRCA1 and BRCA2 genes are crucial for double-strand break repair by homologous recombination, and mutations in these genes are responsible for most familial breast carcinomas.”

Stromal fibroblast activation and their potential association with uterine fibroids (Review) Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA

To which countries do European psychiatric trainees want to move to and why? “A high number of psychiatric trainees considered moving to another country, and their motivation largely reflects the substantial salary differences. These findings suggest tackling financial conditions and academic opportunities.”

Clinical trials for COVID-19 should include sex as a variable “The number of COVID-19 cases appears to be comparable between men and women, but the severity of disease and death is two times greater for men than for women.”

Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data “BM and SREs are common problems in non-trial breast cancer populations. Patient demographics, clinical stage, tumor pathological type, molecular receptors status are significantly risk factors…”

Pyrosequencing quantified methylation level of BRCA1 promoter as prognostic factor for survival in breast cancer patient “Breast cancer is the most common noncutaneous cancer and the leading cause of cancer deaths among women…”


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